• Less than 1% (0.5%) of patients in the unmatched intervention group reported a skin rash, with no adverse effects or serious adverse effects reported by clinicians at the participating study sites.1
Topical painkillers, or analgesics, are sprayed on, rubbed in or applied as patches onto the skin over painful muscles or joints.
# Reductions in the interference of pain with activities of daily living were also noted. Importantly, the topical compounded formulations were associated with reductions in the use of concurrent pain medications, including oral opioid analgesics. Randomized, controlled trials will confirm the efficacy and safety results reported here.1
HAS SHIFTED TO
Pain Relief Patch
In July 2017, the Journal of Pain Management published a comparison of transdermal OTC Lidocaine 3.6% and Menthol 1.25% with Rx Lidocaine 5% and placebo for back pain and arthritis. 3
The study demonstrated that there was no difference in the levels of pain relief and quality of life between the menthol and lidocaine patch over the counter product and the prescription 5% Rx Lidocaine patch
Lidocaine Pain Patch
In October 2017, the Journal of Pain Research published a study: “Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics study.”1
Patients were all being treated with Rx oral NSAIDs, prescription opioids or both at start of intervention with compounded topical agents;
NSAIDs (eg, naproxen sodium, celecoxib, meloxicam), prescription opioids (eg, fentanyl, hydrocodone, hydromorphone, morphine, or oxycodone).
The key insight to this preliminary study employed compounded topical (Flurbiprofen, Diclofenac Ketoprofen) NSAID creams on moderate to severe pain sufferers of arthritic, musculoskeletal, or neuralgic pain.
Topical analgesics appear to be effective and safe for the treatment of chronic pain, with randomized controlled trials needed to confirm these findings.
Results suggest that the topical analgesics are effective and safe for the relief of moderately severe chronic pain attributed to arthritis, neuropathic conditions, and musculoskeletal disorders.
The study concluded, although preliminary, that topical NSAIDs appear to be safe and effective to treat chronic pain.
Importantly, the study showed a de-escalation of oral Rx NSAID and opioid use:
• Over 50% of opioid users were off opioids at the 6 month mark
• Reductions in the interference of pain with activities of daily living were also noted.
• Importantly, the topical compounded formulations were associated with reductions in the use of concurrent pain medications, including oral opioid analgesics. Randomized, controlled trials will confirm the efficacy and safety results reported here.1
Every patient with chronic pain must be medically evaluated to determine if the pain is peripheral, central, or a combination of both. Biorexo encourages you to speak to pain specialist doctors and apply a multidisciplinary rehabiliation approach.