AN OPIOID ALTERNATIVE

For Pain Management
Lidocaine 4% plus Menthol 1.25% Patch

Using topical analgesics such as Biorexo® in first-line treatment

Chronic Pain relief

for

# neuropathic
conditions

may feel like a shooting or burning pain

# arthritis

may feel like a dull ache or a burning sensation

# musculoskeletal
disorders

may feel like muscles have been pulled or overworked

Topical analgesics are safe, effective for chronic pain.1

The Centers for Disease Control and Prevention (CDC) issued guidance and training modules on prescribing opioids for chronic pain. In module 2, “Treating Chronic Pain with Opioids”, the CDC suggests topical analgesics should be considered a first-line treatment for pain.2

• Less than 1% (0.5%) of patients in the unmatched intervention group reported a skin rash, with no adverse effects or serious adverse effects reported by clinicians at the participating study sites.1

• Examples include: Lidocaine, Capsaicin, Topical Nonsteroidal anti-inflammatory drugs (NSAIDs)2

Topical painkillers, or analgesics, are sprayed on, rubbed in or applied as patches onto the skin over painful muscles or joints.

Although all are designed to relieve pain,

different products use different ingredients.

# Reductions in the interference of pain with activities of daily living were also noted. Importantly, the topical compounded formulations were associated with reductions in the use of concurrent pain medications, including oral opioid analgesics. Randomized, controlled trials will confirm the efficacy and safety results reported here.1

The

Lidocaine Patch

HAS SHIFTED TO

Lidocaine + Menthol

Pain Relief Patch

Lidocaine

4%

Menthol

+1.25%

Why Lidocaine and Menthol ?

Pain Patch

The Journal of Pain Management

In July 2017, the Journal of Pain Management published a comparison of transdermal OTC Lidocaine 3.6% and Menthol 1.25% with Rx Lidocaine 5% and placebo for back pain and arthritis. 3

The study demonstrated that there was no difference in the levels of pain relief and quality of life between the menthol and lidocaine patch over the counter product and the prescription 5% Rx Lidocaine patch

Use Topical Analgesics for Chronic Pain Relief

Lidocaine Pain Patch

In October 2017, the Journal of Pain Research published a study: “Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics study.”1

Patients were all being treated with Rx oral NSAIDs, prescription opioids or both at start of intervention with compounded topical agents;
NSAIDs (eg, naproxen sodium, celecoxib, meloxicam), prescription opioids (eg, fentanyl, hydrocodone, hydromorphone, morphine, or oxycodone).
The key insight to this preliminary study employed compounded topical (Flurbiprofen, Diclofenac Ketoprofen) NSAID creams on moderate to severe pain sufferers of arthritic, musculoskeletal, or neuralgic pain.
Topical analgesics appear to be effective and safe for the treatment of chronic pain, with randomized controlled trials needed to confirm these findings.
Results suggest that the topical analgesics are effective and safe for the relief of moderately severe chronic pain attributed to arthritis, neuropathic conditions, and musculoskeletal disorders.

Over

50%
of opioid users were off opioids at the 6 month mark

The study concluded, although preliminary, that topical NSAIDs appear to be safe and effective to treat chronic pain.
Importantly, the study showed a de-escalation of oral Rx NSAID and opioid use:
• Over 50% of opioid users were off opioids at the 6 month mark
• Reductions in the interference of pain with activities of daily living were also noted.
• Importantly, the topical compounded formulations were associated with reductions in the use of concurrent pain medications, including oral opioid analgesics. Randomized, controlled trials will confirm the efficacy and safety results reported here.1

Do you have

Chronic Pain ?
pain experienced for 3+ months

commonly experienced in

Elbow Pain

Back Pain

Hip Pain

Shoulder Pain

Knee Pain

Neck Pain

Every patient with chronic pain must be medically evaluated to determine if the pain is peripheral, central, or a combination of both. Biorexo encourages you to speak to pain specialist doctors and apply a multidisciplinary rehabiliation approach.

Biorexo Guesstimate Success Rate

20%

FOR THE FIRST TIME

65%

FOR THE REPEAT PLAYER

70%

FOR THE VETERAN

Increase your pain relief

Rehabilitation
is a learning process
Biorexo In Consultation With Patient

Prevention

Better Sleep
Activity Pacing
Healthy Lifestyle

Psychological

Relaxation training
Social Support
Counselling

Physical

Exercise
Massage
Physiotherapy

Pharmaceutical

Improve Mobility & Sleep
Match medicine to pain type
Pain Specialist
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